Apejuwe kukuru:
Nọmba CAS: 472-15-1
Ilana molikula:C30H48O3
iwuwo molikula: 456.71
Ilana kemikali:
| Alaye ipilẹ | |
| Orukọ ọja | Betulinic acid |
| Ipele | Pharma ite |
| Ifarahan | Funfun tabi pa-funfun |
| Ayẹwo | 98% |
| Igbesi aye selifu | ọdun meji 2 |
| Iṣakojọpọ | 25kg / ilu |
| Ipo | Idurosinsin, ṣugbọn itaja dara. Ibamu pẹlu awọn aṣoju oxidizing ti o lagbara, kalisiomu gluconate, barbiturates, iṣuu magnẹsia sulfate, phenytoin, awọn vitamin iṣuu soda ẹgbẹ B. |
Apejuwe
Betulinic acid (472-15-1) jẹ Lupane triterpenoid adayeba lati igi birch funfun (Betula pubescens). Nfa apoptosis ni orisirisi awọn laini sẹẹli.1 Nfa mitochondrial permeability transition pore opening.2
Lo
Acid Betulinic jẹ triterpenoid pentacyclic adayeba. Betulinic Acid ṣe afihan egboogi-iredodo ati iṣẹ ṣiṣe anti-HIV. Betulinic Acid yiyan nfa apoptosis sinu awọn sẹẹli tumo nipasẹ mimuuṣiṣẹ taara ipa ọna mitochondrial ti apoptosis nipasẹ p53- ati ẹrọ ominira CD95. Betulinic Acid tun ṣafihan iṣẹ agonist TGR5.
Betulinic acid (BetA) ti lo: +
1.lati ṣe idanwo awọn ipa rẹ bi oluranlowo antiviral lodi si ọlọjẹ Dengue (DENV).
2.bi sterol ilana eleto-abuda amuaradagba (SREBP) inhibitor lati repress awọn ora ti iṣelọpọ agbara ati afikun ti ko o cell kidirin cell carcinoma (ccRCC) ẹyin.
3.gẹgẹbi itọju kan lati ṣe idanwo awọn ohun-ini egboogi-tumor fun ṣiṣeeṣe sẹẹli ati awọn ayẹwo iku apoptotic ni awọn awoṣe myeloma pupọ.
Iwadi Anticancer
Apapọ yii jẹ triterpene pentacyclic ti a gba lati ọdọ Betula ati awọn eya Zizyphus, eyiti o ṣe afihan cytotoxicity yiyan si awọn sẹẹli melanoma eniyan (Shoeb2006). O n ṣe awọn ẹya atẹgun ti o ni ifaseyin, mu MAPK kasikedi ṣiṣẹ, inhibitstopoisomerase I, ṣe idiwọ angiogenesis, ṣe iyipada awọn transcriptionalactivators pro-idagbasoke, ṣe atunṣe iṣẹ ṣiṣe ti aminopeptidase-N, ati nitorinaa inducesapoptosis ninu awọn sẹẹli alakan (Desai et al. 2008; Fulda 2008).
Ti ibi aṣayan iṣẹ-ṣiṣe
Adayeba triterpenoid ti o han egboogi-HIV ati antitumor aṣayan iṣẹ-ṣiṣe. Ṣiṣejade iṣelọpọ ti awọn eya atẹgun ifaseyin (ROS) ati mu NF-κ B. Ṣe afihan iṣẹ-ṣiṣe agonist TRG5 (EC 50 = 1.04 μ M).
Biochem/physiol Awọn iṣẹ
Betulinic acid, triterpene pentacyclic kan, yiyan nfa apoptosis sinu awọn sẹẹli tumo nipasẹ mimuuṣiṣẹ taara ipa ọna mitochondrial ti apoptosis nipasẹ ọna p53- ati CD95 ominira.
